平安! 发表于 2011-11-9 19:57 2 ^* B7 J$ s, N" T; I
Pazopanib (100 mg/kg/day free base equivalent) ! Q% A# r7 N6 ]2 i$ I Q- o0 M1 Z
这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。
4 T- S; |9 {, g5 f p/ t搜索了一下,原料一大堆。
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b' m# m2 E1 O) o v, Q6 P8 c( S- T对不起!100mg/kg是用于移植瘤的,我弄错了。- ]( ^3 v9 o0 v: w, T
( w2 J; n) t1 b/ G以下是正版说明书的推荐用量。
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--------------------- DOSAGE AND ADMINISTRATION ----------------# k$ N7 [# u6 g5 G) D5 H
* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) : O* Y" R# C: t9 l7 k; n
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) . P" ~/ O9 i) t0 X! e1 E Z( [
---------------------DOSAGE FORMS AND STRENGTHS --------------7 { z5 K/ n9 v B
200 mg tablets. (3)
3 e1 ]0 E- W9 T3 H- K0 c, ]3 E-------------------------------CONTRAINDICATIONS------------------------ |