发给老马备查:6 t" N0 [6 z O+ \% z" A
滴水察海(69304838) 15:23:23) Y4 A% m: K, `( W4 `( v0 L! r
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱% p+ l. J, u O+ D; ]& d N! p. V$ z
吉非替尼和S-1连用的依据
7 P1 C& q& q! E; s4 XGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
% N2 F; `3 ~' m0 r1 \是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
; u T3 \" C6 }$ L; O w2 [7 T这样是不是推理出,耐药后,可以用S-1和培美了?
b2 k) t- z; u/ u& e* s结论:) I, D8 q% y) N, s( J$ r
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |