发给老马备查:* i; L3 e, n; \, O1 d, ?. [- _
滴水察海(69304838) 15:23:23 {" ]# }: P3 q' w; x+ L
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
! Z" v/ [1 p+ F( Z; I8 B) j# j吉非替尼和S-1连用的依据
& {! @5 @* M! k/ V+ R' m! w& W% [7 TGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.) p3 a& L) T) X- k# u/ T* Y
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达- }3 u% s1 L+ ?* ?
这样是不是推理出,耐药后,可以用S-1和培美了?; m8 K7 T9 `& @: S
结论:
, I W/ k2 I7 k8 i7 ^- f如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |