发给老马备查:' K+ Q8 Z, }! e. `
滴水察海(69304838) 15:23:23# L* V+ d9 d7 j, U; s' K
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
9 ?) P2 I1 @9 F吉非替尼和S-1连用的依据/ `/ G0 j4 j4 \: A# k y+ W5 N
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.2 |8 g j* ~0 |$ Q% j- a* h4 c$ F, ?! }
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' U* S1 Q- L- j, R这样是不是推理出,耐药后,可以用S-1和培美了?: B( m+ o* }2 M2 a7 h n
结论:) ^' i. S4 c$ @
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |