发给老马备查:
3 k# }1 H+ _" y" {滴水察海(69304838) 15:23:23
& G: @ y5 f }; V7 T# ` D+ G老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱, C, c8 E" Q3 X+ F6 F- ?& Q, G
吉非替尼和S-1连用的依据
0 a. Y. ~. T( b8 W6 S, }8 p5 iGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.4 k; y8 z" q7 M1 S
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, C4 x# S. B5 A! J" b: ^& i/ q9 {
这样是不是推理出,耐药后,可以用S-1和培美了?
% z7 b2 R: R, R8 h, R5 ^结论: E$ d3 y- n% l# U9 g. |
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |